There are other note taking apps out there, but I have always found they are just "yet another thing" to do, instead of making my life easier. My desktop is maybe chaotic, but it works. CintaNotes, however, feels natural and sits in the system tray ready to spring into action whenever you need it: highlight text, hot key, you're done. Easy.
Fantastic program. Can't say enough good things about it. Great design. Ultra ergonomic. Runs in the background. Simple, effective, rock solid. CintaNotes would be worth ten times the asking price. Not affiliated, BTW. Just like to do what I can to publicize good programs.